The kidney is a very active organ which depends upon a well-maintained blood flow to function properly. If blood flow is disrupted (ischemia), and the restored (reperfusion), and intense inflammatory reaction results. This, in turn, causes the swelling and death of kidney cells, especially within the specialized cell of the kidney tubules. As an example, the blood flow to a pig’s kidney was cut off for 45 minutes and then restored. As a consequence, tubular cells became pale and swollen, a classical indication of injury (top image; control). In contrast, treatment with cibinetide immediately following the restoration of blood flow noticeably reduced inflammation and kidney cell loss (bottom image), resulting in preserved kidney function. Additionally, cibinetide significantly reduced scarring in the kidney following injury, a major cause of progressive kidney damage caused by numerous different types of injury.